Significance of high expression of PTP1B in the valuation of progenosis of ovarian cancer
10.13315/j.cnki.cjcep.2019.03.007
- VernacularTitle:PTP1B蛋白高表达在卵巢癌临床预后评价中的意义
- Author:
Qing-Qun PENG
1
;
Zhi-Yan XU
;
Yue-Min GAN
;
Rui-Jun ZHAO
Author Information
1. 江西省乐平市妇幼保健院妇产科
- Keywords:
ovarian neoplasm;
PTP1B;
immunohistochemistry;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2019;35(3):282-285
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expressions of PTP1B in epithelial ovarian cancer tissues and to analysis its correlation with clinical pathological and survival significance.Methods The expression of PTP1B in ovarian cancer tissues was detected by Oncomine database and immunohistochemistry.The relationships between PTP1B expression and clinicopathological features, including prognosis significance, were analyzed. Results Oncomine database showed that the mRNA expression of PTP1B in ovarian cancer was significantly higher than that in normal tissues (P<0.001). Immunohistochemical staining showed that PTP1B expression was significantly correlation with FIGO stage (P<0.001), omentum majus metastasis (P=0.002). Kaplan-Meier analyses revealed that ovarian cancer patients with high PTP1B expression tumors had a significantly worse overall survival rate than those with low PTP1B expression tumors (P<0.001). Multivariate analysis showed that FIGO stage, PTP1B expression were independent survival predictors.Conclusion PTP1B expression may be involved in the tumor progression and poor prognosis of patients with ovarian cancer, and it might be used as one of the valuable markers for poor prognosis in patients with ovarian cancer.
