Expression and clinical significance of P-selectin and HPA in benign and malignant hydatidform mole tissues
10.13315/j.cnki.cjcep.2019.03.005
- VernacularTitle:良、恶性葡萄胎组织中P-选择素和HPA的表达及其临床意义
- Author:
Jie-Min QI
1
;
Shu-Li YU
;
Xing-Wu BAI
;
Chuang WANG
Author Information
1. 承德医学院病理学教研室
- Keywords:
hydatidform mole;
P-selectin;
HPA;
immunohistochemistry;
RT-PCR
- From:
Chinese Journal of Clinical and Experimental Pathology
2019;35(3):273-277
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression characteristics and significance of P-selectin and HPA in benign and malignant hydatidform mole tissues. Methods By using immunohistochemical technique SP and RT-PCR, the expression of Pselectin and HPA was detected in 40 cases of benign hydatidiform mole tissues, and 12 malignant hydatidiform mole tissues.Meanwhile, 40 cases of normal placental villi tissues were observed. Results The protein positive rate and protein relative quantity expression and the mRNA relative quantity expression of P-selectin and HPA were gradually increasing in normal placenta villi tissues, benign hydatidiform mole tissues, and malignant hydatidiform mole tissues. The differences between groups were statistically significant (all P<0.05). The expression of P-selectin and HPA showed positive correlation (all P<0.05) in benign and malignant hydatidform mole tissues. Conclusion The over-expression of P-selectin and HPA promotes the occurrence and development of hydatidform mole. The detection of the expression levels of P-selectin and HPA is of great significance for the differential diagnosis and prognosis assessment of benign and malignant hydatidform mole. It could become a biological predictor of malignant development of hydatidform mole.
