Expression and clinical significance of N-Myc and p53 in prostate cancer tissues
10.13315/j.cnki.cjcep.2019.01.003
- VernacularTitle:前列腺癌组织中N-Myc、p53的表达及其临床意义
- Author:
Gui-Fang HE
1
;
Xiao-Juan HUANG
;
Lu-Lu ZHENG
;
Li ZHANG
;
Ling-Fan XU
;
Chao-Zhao LIANG
;
Yong-Ping CAI
;
Yu YIN
Author Information
1. 安徽医科大学病理学教研室
- Keywords:
prostate neoplasm;
benign prostatic hyperplasia;
N-Myc;
p53;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2019;35(1):10-13
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To detect the expression of N-Myc and p53 in the tissues of prostate cancer (PCa) patients and to explore the relationship between them and their significance.Methods A total of 63 patients with PCa and 50 patients with benign prostatic hyperplasia (BPH) who underwent prostate surgery at the First Affiliated Hospital of Anhui Medical University were recruited in 2015-2016. The expression of N-Myc and p53 in pathological tissues were detected by immunohistochemistry of MaxVision method. Results The expression of N-Myc and p53 in PCa tissues was increased (P < 0.05). The expression of N-Myc and p53 in PCa tissues was correlated with bone metastases and TNM stage (P < 0.05), but not related to patient age, preoperative PSA level and other factors (P> 0.05). In addition, the expression of p53 was also correlated with Gleason score.Conclusion The high expression of N-Myc and p53 in PCa may involved in the malignant progression and metastasis of prostate cancer, and it is expected to become a new target for detecting PCa metastasis.
