Advances in the role of vascular endothelial system in the pathogenesis of vasovagal syncope in children
10.3969/j.issn.1000-3606.2019.01.015
- VernacularTitle:血管内皮系统在儿童血管迷走性晕厥发病中的作用研究进展
- Author:
Tingting CHEN
1
;
Min HUANG
;
Guoqing ZHANG
;
Yujuan HUANG
Author Information
1. 上海市儿童医院 上海交通大学附属儿童医院
- Keywords:
vasovagal syncope;
vascular endothelial system;
child
- From:
Journal of Clinical Pediatrics
2019;37(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Vasovagal syncope (VVS) is the most common cause of unexplained syncope in children. The etiology of VVS is complex, and its diagnosis is mainly based on clinical manifestations and head-up tilt test (HUT) . It has been pointed out that neuroendocrine system plays an important role in the pathogenesis of syncope. HUT-induced syncope is accompanied by abnormal neurohumoral activation. The changes of plasma concentration of endothelin-1 and nitric oxide secreted by endothelial system before and after VVS syncope in children suggest that endothelial system is involved in the occurrence of VVS in children. This article reviews the research on the involvement of vascular endothelial system in the pathogenesis of VVS in children.