Effect of troponin Ⅰ autoantibodies on the quality of life and prognosis in patients with ischemic cardiomyopathy
10.3760/cma.j.issn.1671-0282.2019.02.023
- VernacularTitle:肌钙蛋白Ⅰ自身抗体对缺血性心肌病患者生活质量及预后的影响
- Author:
Bing LI
1
;
Yudong MIAO
;
Xiaoyu LIU
;
Hongyan DUAN
;
Yong WANG
;
Liuyi WANG
Author Information
1. 河南省人民医院(郑州大学人民医院)全科医学科
- Keywords:
Ischemic cardiomyopathy;
Troponin Ⅰ-autoantibodies;
Prognosis;
Quality of life
- From:
Chinese Journal of Emergency Medicine
2019;28(2):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of troponin Ⅰ (anti-cTnⅠ) autoantibodies on the quality of life and prognosis in patients with ischemic cardiomyopathy.Methods Patients hospitalized in Henan Provincial People's Hospital for ischemic cardiomyopathy from June 2016 to June 2017 were enrolled.At the same time,physical examiners were selected as the control group.Anti-cTnⅠ autoantibodies were detected in the serum from the patients and control group,which were expressed as the OD value.After six months,all patients were followed up,including death,times of readmission,instrument treatment (CRT-P or CRT-D) or heart transplantation,and quality of life questionnaire (SF-36).The effect of anti-cTnⅠ autoantibodies on the prognosis and quality of life were analyzed.Results In 127 patients with ischemic cardiomyopathy,the OD value of anti-cTnI autoantibodies were significantly higher than that in the control group[(0.55 ± 0.24) vs (0.46 ± 0.07),P＜0.05].With a positive standard of more than 0.67,26 patients with ischemic cardiomyopathy were tested positive for anti-cTnⅠ autoantibodies,with a positive rate of 20.5％.After 6 months of outpatient or telephone follow-up,9 patients were lost to follow-up,and 118 patients were followed up,including 24 patients with positive anti-cTnⅠ autoantibodies.Compared with patients with negative anti-cTnⅠ autoantibodies,the times of readmission in patients with positive anti-cTnⅠ autoantibodies increased significantly[(1.42 ± 0.79)vs (0.30 ± 0.55),P＜0.01] and the physiological function was decreased significantly[(56 ± 19.4) vs (67 ± 20.8),P=0.032].The physiological function,vitality and social function of patients with reduced ejection fraction in the anti-cTnⅠ autoantibodies positive group were significantly worse than those in the anti-cTnI autoantibodies negative group,but there was no significant difference in quality of life between the anti-cTnⅠ autoantibodies positive and negative groups in the patients with preserved and median ejection fraction.Conclusions Patients with ischemic cardiomyopathy of seropositivity for anti-cTnⅠ autoantibodies have worse prognosis and quality of life,especially in those with reduced ejection fraction.
