Sodium citrate anticoagulation in continuous plasma adsorption treatment of clinical research
10.3760/cma.j.issn.1671-0282.2018.10.018
- VernacularTitle:枸橼酸钠抗凝在连续性血浆吸附治疗中的应用
- Author:
Pengbo YAN
1
;
Guoqiang LI
;
Liang SUN
;
Guofeng LI
;
Xin YU
;
Jinmei QUAN
;
Cuihua LIU
;
Guoli WANG
Author Information
1. 武警后勤学院附属医院呼吸与重症医学科
- Keywords:
Acute drug poisoning;
Sodium citrate;
Plasma adsorption;
Continuity;
Feasibility;
Safery
- From:
Chinese Journal of Emergency Medicine
2018;27(10):1154-1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective Explore the sodium citrate anticoagulation in the continuity of plasma adsorption closed-circuit circulation of anticoagulation therapy method and effect. Methods Line into the continuity of plasma adsorption treatment of 156 cases of acute drug poisoning patients were randomly(random number) divided into two groups, 78 cases in each group, respectively adopt low molecular heparin (group A), sodium citrate anticoagulation (group B). Contrast analysis of two groups after the therapy began 30 min, 3 h, 6 h before the filter in patients with pressure, transmembrane pressure, pressure drop, at the same time to compare two groups of 10 min before the start of treatment, after treatment began to 3 h, 6 h platelet, coagulation time live enzymes, vein in the body of free Ca2+, Na+and HCO3- 24 h and internal bleeding. Results Two groups in gender, age, clinical diagnosis, blood purification time comparative differences had no statistical significance (P>0.05);Two groups of 30 min after the start of treatment, 3 h, 6 h patients before pressure, transmembrane pressure, filter pressure drop compared differences were no statistical significance (P>0.05); Part of coagulation treatment after low molecular heparin group live enzymes the sodium citrate group significantly prolonged (P<0.01);Platelets, HCO3- the two groups after treatment, intravenous free Ca2+ and Na+ differences had no statistical significance (P>0.05). Conclusions In the continuous plasma adsorption treatment process using sodium citrate anticoagulation with clinical feasibility, safety.
