Combination use of TACE and 125I seed implantation for primary hepatic cancer complicated by portal vein tumor thrombus: a meta-analysis
10.3969/j.issn.1008-794X.2019.03.013
- VernacularTitle:TACE联合125I放射性粒子植入治疗原发性肝癌合并门静脉癌栓的荟萃分析
- Author:
Fan ZHOU
1
;
Qian ZHAO
;
Hao XU
;
Maoheng ZU
;
Jia LIN
;
Wenyao ZHANG
;
Lei MA
;
Wei XU
Author Information
1. 徐州医科大学附属医院介入放射科 221006 江苏
- Keywords:
transcatheter arterial chemoembolization;
125I seed;
primary liver cancer;
portal vein tumor thrombus;
meta-analysis
- From:
Journal of Interventional Radiology
2019;28(3):268-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical effect and safety of transcatheter arterial chemoembolization (TACE) combined with 125I seed implantation with those of pure TACE in treating primary liver cancer (PHC) complicated by portal vein tumor thrombus (PVTT) . Methods Computer and manual retrieval of PubMed, Cochrane Library, CBM, Wan Fang Database, China National Knowledge Internet and other databases was conducted to collect the retrospective cohort studies on the comparison of the clinical effect and safety of the combination use of TACE and 125I seed implantation with those of simple TACE in treating PHC complicated by PVTT, from which the relevant data were extracted. The quality of extracted documents was assessed according to the standard of Cochrane manual. Results A total of eight articles containing 822 patients were included in this study. Meta analysis indicated that both the effective rate and disease control rate for PHC complicated by PVTT in TACE plus 125I seed implantation group were significantly higher than those in pure TACE group, and the differences between the two groups were statistically significant (P<0.05) . The half-year, one-year and 2-year survival rates of TACE plus 125I seed implantation group were better than those of pure TACE group, and the differences between the two groups were statistically significant (P<0.05) . No statistically significant differences in the incidence of severe complications existed between the two groups (P>0.05) . Conclusion In treating PHC complicated by PVTT, the curative effect of TACE plus 125I seed implantation is superior to pure TACE. No obvious difference in the incidence of severe complications exists between the two groups.
