A new integrated portable biliary internal-external drainage catheter loaded with 125I seeds: its design and clinical application
10.3969/j.issn.1008-794X.2019.03.010
- VernacularTitle:新型一体化可携带125I粒子胆道内外引流管的设计与临床应用
- Author:
Dechao JIAO
1
;
Xueliang ZHOU
;
Xinwei HAN
;
Zongming LI
;
Ming ZHU
;
Jianjian CHEN
;
Liangliang BAI
;
Guosheng WANG
Author Information
1. 郑州大学第一附属医院 450052
- Keywords:
125I seed;
brachytherapy;
biliary obstruction;
cholangiocarcinoma
- From:
Journal of Interventional Radiology
2019;28(3):252-257
- CountryChina
- Language:Chinese
-
Abstract:
Objective To design a new integrated portable biliary internal-external drainage catheter carrying125 I seeds used for the treatment of malignant biliary obstruction lesions so as to achieve the dual curative effects of biliary drainage and brachytherapy. Methods A total of 15 patients with malignant obstructive jaundice, who were admitted to the First Affiliated Hospital of Zhengzhou University, China, during the period from September 2016 to January 2018, were enrolled in this study. Biliary stent implantation was performed in all patients, which was followed by insertion of a new integrated portable biliary internal-external drainage catheter carrying125 I seeds. The technical success rate, clinical success rate, complications, stent patency time and patient survival rate were evaluated. Results The placement of the drainage tube was simple and smooth, and the technical procedure was successful in all patients. One month after treatment, the bilirubin level was decreased significantly when compared with preoperative one (P<0.01), while the blood indexes and immunological indicators showed no obvious changes (P>0.05) . After treatment, 2 patients (13.3％) developed cholangitis and 2 patients (13.3％) had small amount of biliary bleeding, which returned to normal after symptomatic treatment. No severe complications such as perforation of bile duct, massive bleeding, radiation enteritis and radioactive source leakage, etc., occurred. The patients were followed up for 55-402 days, 6 patients (40.0％) developed biliary re-obstruction. The median patency time of stent was 255 days, and 6-month stent patency rate was 64.5％. Five patients died and 10 patients survived, the 9-month survival rate was 64.3％, the median survival time was 368 days. Conclusion By using the new integrated portable biliary internal-external drainage catheter carrying125 I seeds, the effects of bile drainage and brachytherapy can be simultaneously achieved. Preliminary clinical practice indicates that this new drainage catheter is feasible, safe and effective, although its long-term efficacy needs to be clarified with further follow-up observations and controlled studies.
