Clinical observation of modified Chushi-Jiedu decoction combined with external application of purslane in the treatment of acute eczema with damp heat and skin retention
10.3760/cma.j.issn.1673-4246.2019.04.010
- VernacularTitle:除湿解毒汤联合马齿苋外敷治疗湿热蕴肤型急性湿疹
- Author:
Ling ZHANG
1
;
Sucai LIN
;
Yongping ZHENG
Author Information
1. 广东省中山市中医院皮肤科 528400
- Keywords:
Eczema;
Plastering therapy;
Chushi-Jiedu decoction;
Portulacae herba;
Damp heat accumulation skin type;
Syndrome differentiation classification;
Immunomodulation
- From:
International Journal of Traditional Chinese Medicine
2019;41(4):361-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and adverse reaction of modified Chushi-Jiedu decoction combined with external application of purslane in the treatment of acute eczema with damp heat and skin retention. Methods A total of 80 patients with damp heat skin type acute eczema were collected in the department of Dermatology of our hospital from January to December of 2017, and the patients were randomly divided into two groups, each 40 cases. The control group was treated with Cetirizine Hydrochloride Tablets and hydrocortisone ointment, and the observation group was treated with modified Chushi-Jiedu decoction combined with external application of purslane. The effects and adverse reaction of two groups were compared after 2 weeks of treatment. Results The total effective rate of the observation group was 97.5% (39/40), and the control group was 80.0% (32/40), where the comparison difference between the two groups was statistically significant (χ2=6.135, P=0.013). After treatment, the lesion area and lesion form and pruritus scores of the observation group were significantly lower than those of the control group (t value were 5.060, 4.391, 8.761, P<0.01); the levels of IL-4 (0.15 ± 0.06 ng/L vs. 0.31 ± 0.08 ng/L, t=10.119), TNF-α (19.03 ± 3.26 ng/L vs. 25.58 ± 4.03 ng/L, t=7.992) of the observation group were significantly lower than those of the control group (P<0.01). The levels of CD4+(33.42% ± 3.53 % vs. 27.38% ± 3.06%, t=8.177), CD4+/CD8+(1.37 ± 0.28 vs. 0.97 ± 0.19, t=7.170) in observation group were significantly higher than the control group (P<0.01), and the levels of CD8+(24.32% ± 2.10% vs. 28.03% ± 2.51%, t=7.476) was significantly lower than the control group ( P<0.01). Conclusions The modificatied Chushi-Jiedu decoction combined with external application of purslane is safe and effective for the treatment of acute eczema with damp heat and skin type, and it can alleviate the inflammatory reaction and improve the immunity of the body.
