Components analysis and anti-psoriatic effect of standard decoction of Lithospermum
10.3760/cma.j.issn.1673-4246.2019.03.014
- VernacularTitle:紫草标准汤剂成分分析及其抗银屑病作用研究
- Author:
Wenjing ZHANG
1
;
Jing FU
;
Lu ZHANG
;
Tianyuan WANG
;
Xuyang HAN
;
Ping LI
;
Zuping ZENG
Author Information
1. 首都医科大学附属北京中医医院(中医药临床医学院) 100010
- Keywords:
Arnebiae radix;
Standard decoction;
Polysaccharides;
Phenolic acid;
Psoriasis
- From:
International Journal of Traditional Chinese Medicine
2019;41(3):273-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the main ingredients and investigate the anti-psoriasis effect in the standard decoction of Lithospermum. Methods The extraction rate was determined by extract determination method, and the content of total polysaccharide and total phenolic acid was evaluated by spectrophotometry. Moreover, the effects of different concentrations of the standard decoction of Lithospermum on skin lesions induced by imiquimod (IMQ) in psoriatic mice were observed. Results The extracting rate was 4.65 ％, the total polysaccharide content was 1.182 mg/ml and the total phenolic acid content was 3.506 mg/ml. The different concentrations of the standard decoction of Lithospermum could ameliorate the scales, erythema and psoriasis-like mice skin and reduce the thickness of epidermis. Conclusions The standard decoction of Lithospermum could improve the psoriasis-like lesions induced by imiquimod in mice and possess the anti-psoriasis effect.
