The effect of warming kidney and dredging collaterals on the clinical effect and urinary C5b-9 in patients with idiopathic membranous nephropathy
10.3760/cma.j.issn.1673-4246.2019.03.005
- VernacularTitle:温肾通络法用于特发性膜性肾病的治疗
- Author:
Chaoye LIU
1
;
Junfu HU
;
Weiying ZHANG
;
Ningbo ZHAO
;
Hongli QIAN
;
Hongtong CHEN
;
Chong XIONG
;
Caidi GONG
Author Information
1. 广西中医药大学第一附属医院肾病科
- Keywords:
Glomerulonephritis;
membranous;
Syndrome of yang deficiency of spleen and kidney;
Syndrome of static blood blocking collaterals;
Tao Hong Si Wu Tang;
Jingui-Shenqi pill;
Urinary albumin excretion rate;
Urine C5b-9
- From:
International Journal of Traditional Chinese Medicine
2019;41(3):229-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of the method of warming kidney and dredging collaterals on the clinical effect and the content of urine C5b-9 in patients with idiopathic membranous nephropathy with spleen kidney yang deficiency and blood stasis. Methods A total of 60 idiopathic membranous nephropathy patients with spleen kidney yang deficiency and blood stasis type were randomly divided into the conventional western medicine treatment group (control group), Jingui-Shenqi pill and Taohong-Siwu decoction plus conventional western medicine treatment group (treatment group), 30 cases in each group. The Scr was detected by deproteinized alkaline picric acid method, and BUN was detected by rate method, and serum albumin (ALb) was detected by bromocresol green dye binding method, and 24 hours urinary protein was measured by pyrogallol red colorimetry, and the double antibody sandwich ELISA method was used for detection of urinary C5b-9. Results The Jingui-Shenqi pill combined with Taohong-Siwu decoction plus conventional western medicine treatment has obvious curative effect on patients. The total effective rate was 83.3 in the treatment group (25/30), and the control group was 60％ (18/30). After treatment, the Alb (33.5 ± 7.95 g/L vs. 28.8 ± 6.10 g/L, t=2.569) in the treatment groupwas significantly higher than that in the conventional treatment group (P<0.01). While the 24 h urine protein (2.40 ± 0.92 g/24 h vs.3.60 ± 2.3 g/24 h, t=2.653), the contents of C5b-9 in urine(42.5 ± 17.50 ng/mg vs.71 ± 25.2 ng/mg, t=5.088) in the treatment group were significantly lower than those in the conventional treatment group (P<0.01). Conclusions The method of warming kidney and dredging collaterals can improve the clinical symptoms, improve serum albumin level, reduce the 24 hour urine protein and urinary C5b-9 content of idiopathic membranous nephropathy of spleen and kidney yang deficiency and blood stasis type.
