Study on anti-inflammatory and analgesic effect of Xiaozhong-Zhitong granule extraction technology
10.3760/cma.j.issn.1673-4246.2019.02.014
- VernacularTitle:消肿止痛颗粒提取工艺抗炎镇痛药效筛选研究
- Author:
Maobo DU
1
;
Shuzhi LIU
;
Hua JIANG
;
Xiaodong LI
;
Shuo SHEN
;
Yao YAO
;
Aiping HE
Author Information
1. 中国中医科学院中药研究所中药制剂研究中心
- Keywords:
Technology improving (TCD);
Xiaozhong-Zhitong granule;
Extraction;
Analgesia;
Rats;
Mice
- From:
International Journal of Traditional Chinese Medicine
2019;41(2):165-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this paper, the extraction process of Xiaozhong-Zhitong granule (XZG) was investigated. Methods In Process 1, the Panax notoginseng (Burk.) F.H.Chen was extracted with other drugs, and in the process 2, the Panax notoginseng (Burk.) F.H.Chen was crushed and directly used as medicine. Rats were randomly divided into blank group, process 1 group, process 2 group and mixture group.The sample concentration of the process 1 group 1 for the stomach was 2.07 g/ml, and the sample concentration of the process 2 group 1 for the stomach was 1.06 g/ml, and the sample concentration of the mixture group for the stomach was 0.015 g/ml, and blank group gavaged equal volume saline. Anti-inflammatory and analgesic effects of acetic acid writhing test, hot plate test, auricle swelling test and egg white-induced plantar swelling test were evaluated. Results Compared with the blank group after 1, 2, 3, and 4 h after administration, the average writhing number of the mice in the process group 1 and the process 2 group (35.50％ ± 8.06％, 35.00％ ± 7.63％vs. 47.00％ ± 1.45％) significantly decreased (P<0.01), and the auricular swelling degree (46.31％ ± 22.25％, 45.41％ ± 21.43％ vs. 73.89％ ± 15.55％) significantly decreased. And compared with the blank group after 0.5, 1, 2, and 4 h after inflammation, the percentage of pain threshold in the first group and the second group increased (P<0.01). While there was no significant difference in the inhibition rate of paw swelling in each group (P>0.05). Conclusions The design of extraction process of XZG was reasonable; when treating swelling and pain, it was better to put the powder of Panax notoginseng (Burk.) F.H.Chen in XZG.
