Progress of radiotherapy combined with anti-PD-1 / PD-L1 in tumor therapy

VernacularTitle:放疗联合抗PD-1及PD-L1抗体在肿瘤治疗中的进展
Author: Hui LI ¹ ; Yongjian DUAN ; Hong GE
Author Information

1. 河南大学第一附属医院肿瘤科
Keywords: Radiotherapy; Immunotherapy; PD-1; PD-L1
From: Journal of International Oncology 2019;46(1):49-53
CountryChina
Language:Chinese
Abstract: Radiotherapy is widely used in local treatment of tumors. It can not only directly kill tumor cells by damaging DNA,but also have a great impact on the immune system of the body. This effect is not only inhibited,but also more activated. Programmed death-1(PD-1)and its ligand 1(PD-L1)antibody,as the most popular immune checkpoint inhibitor,can inhibit tumor growth by restoring and enhancing the immune killing function of T cells. With the deepening of the study,it is found that the combination of the two treatment of tumor,the curative effect is better than the single mode.