Research progress of anti-PD-1 / PD-L1 immunotherapy biomarkers
10.3760/cma.j.issn.1673-422X.2019.01.009
- VernacularTitle:抗PD-1/PD-L1免疫治疗生物标志物研究进展
- Author:
Huan WANG
1
;
Haiping JIANG
;
Yuan GAO
;
Nong XU
;
Xiongfei YU
Author Information
1. 浙江大学医学院附属第一医院肿瘤内科
- Keywords:
Immunotherapy;
Biological markers;
PD-1;
PD-L1
- From:
Journal of International Oncology
2019;46(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
Immunological checkpoint inhibitors of anti-programmed cell death-1 and programmed cell death ligand-1(PD-L1)have already demonstrated remarkable clinical efficacy for solid tumors,however,the effectiveness of single drug therapy in immunotherapy is not very high. Therefore,exploring the appropriate therapeutic predictive biomarkers so as to accurately identify the potential patients suitable for this therapy has become a research hotspot. Studies have shown that biomarkers such as PD-L1,tumor mutation burden and mismatch repair deficiency may be related to the efficacy of immunotherapy. In-depth analysis and exploration of these markers may provide a basis for determining those patients who are more likely to benefit from check-point inhibitor.
