Branched chain amino acid transferase 1 and malignant tumors
10.3760/cma.j.issn.1673-422X.2019.01.008
- VernacularTitle:支链氨基酸转移酶1与恶性肿瘤
- Author:
Tianxin LYU
1
;
Binglei ZHANG
;
Yongping SONG
Author Information
1. 郑州大学附属肿瘤医院血液科 450008
- Keywords:
Neoplasms;
Branched chain amino acid transaminase 1;
Branched chain amino acid
- From:
Journal of International Oncology
2019;46(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
As a key enzyme that catalyzes the metabolism of branched chain amino acids,branched chain amino acid transferase 1(BCAT1)is often involved in a variety of biosynthetic pathways. Reaserches show that BCAT1 is highly expressed in many kinds of malignant tumors such as leukemia,glioma,nasopharyn-geal carcinoma,gastric cancer and breast cancer,et al,suggesting a close relationship with the proliferation, invasion and metastasis of tumor cells. Thus,BCAT1 plays an important role in the genesis and progression of tumor,and may have the potential to be a new therapeutic target.
