Predictive biomarkers of efficacy to PD-1/PD-L1 inhibitors
10.3760/cma.j.issn.1673-422X.2018.12.011
- VernacularTitle:PD-1/PD-L1抑制剂疗效预测的生物标志物
- Author:
Axiang WANG
1
;
Quanli GAO
Author Information
1. 450008,郑州大学附属肿瘤医院生物免疫治疗科
- Keywords:
Biological markers;
Forecasting;
PD-1/PD-L1
- From:
Journal of International Oncology
2018;45(12):751-755
- CountryChina
- Language:Chinese
-
Abstract:
With the development of tumor precise immunotherapy,it is a hot topic to find biomarkers to predict the response ability of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1).So far,many predictors,such as the PD-L1 expression in tumor tissue,tumor-infiltrating lymphocyte,tumor mutational burden,serum markers and radiographic markers,have shown predictive value in the process of anti-PD-1/PD-L1 immunotherapy.But each predictor has its limitations.
