Autophagy in tumorigenesis and cancer therapy
10.3760/cma.j.issn.1673-422X.2018.12.009
- VernacularTitle:细胞自噬与肿瘤的发生发展及治疗
- Author:
Xin WANG
1
,
2
;
Haiping SONG
;
Ye WANG
;
Hongquan SUN
;
Xuezhen MA
Author Information
1. 266042 青岛大学第二附属医院肿瘤科
2. 青岛市阜外心血管病医院综合内科
- Keywords:
Autophagy;
Neoplasms;
Drug therapy;
Radiotherapy;
Targeted therapy
- From:
Journal of International Oncology
2018;45(12):743-746
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a crucial physiological process for cellular self-renewing and homeostasis,which plays a dual role in both tumorigenesis and anti-tumor treatment.It plays an antineoplastic role by maintaining genomic stability,as well as a protective role in tumorgenesis and progression.Autophagy improves the effectiveness of anti-tumor therapy,meanwhile,it involves in resistance of tumor cells to chemotherapy and irradiation.Using relevant autophagy regulators in different backgrounds is expected to become a new strategy for improving sensitivity of tumor cells to anti-tumor treatment.
