Preleukemic State Preceding Acute Lymphocytic Leukemia in Childhood.
- Author:
Ick Ho SUNG
;
Kwang Yong PARK
;
Sang Il GOO
;
Byeong Heui SON
;
Soon Yong LEE
- Publication Type:Case Report
- Keywords:
Pre-ALL;
Preleukemic state;
Preleukemic phase;
Aplastic presentation of ALL
- MeSH:
Bacterial Infections;
Bone Marrow;
Cough;
Drug Therapy;
Fever;
Humans;
Infant;
Leukemia;
Male;
Pallor;
Pancytopenia;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Precursor Cells, B-Lymphoid;
Sepsis
- From:Korean Journal of Pediatric Hematology-Oncology
1997;4(2):376-382
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECT: Pre-ALL is a very rare preteukemic state, which percedes acute lymphocytic leukemia, while MDS(pre-ANLL), usually the well-known type of preleukemic state, precedes acute non-lymphocytic leukemia. Initially it shows transient pancytopenia without any evidence of leukemia in bone marrow findings, followed by acute lymphocytic leukemia after recovery from pancytopenia of a short period within weeks or months. We report a case with pre-ALL in childhood. CASE: A 15-month-old male baby was admitted with the complaints of fever and cough for 5 days and pallor for 2 weeks prior to admission. On admission, CBC showed pancytopenia without any evidence of leukemia, which was recovered spontaneously in a short period, and then was followed by acute lymphocytic leukemia of CALLA negative, early pre-B cell type. During antileukemic chemotherapy, he had suffered from severe bacterial infections and was finally died of sepsis 8 months after first admission. CONCLUSION: We report a case of pre-ALL in childhood, which was preceded by CALLA negative, early pre-B cell ALL, with a review of the literatures, briefly.
