Uric acid transporter and the balance of serum uric acid
- VernacularTitle:尿酸转运蛋白与血清尿酸平衡
- Author:
Xue-Dong DING
1
;
Cheng-Lu PENG
;
Man-Man LI
;
Jin-Chun LI
;
Jin-Jie WU
Author Information
1. 安徽农业大学动物科技学院 230061 合肥
- Keywords:
uric acid;
glucose transporter 9;
ATP-binding cassette G2;
multidrug resistant protein 4;
organic anion transporter
- From:
Journal of International Pharmaceutical Research
2018;45(9):665-669
- CountryChina
- Language:Chinese
-
Abstract:
During the uric acid production, excretion and reabsorption in the liver, kidney and intestine, several uric acid transporter proteins are involved in these processes. A large number of studies have shown that glucose transporter 9 plays an important role in the uric acid transport in the liver, kidney and intestine, and participates in the uric acid reabsorption. The ATP-binding cassette superfamily G member 2 is mainly expressed in the apical membrane of the proximal tubular epithelial cells of the kidney, which is involved in the uric acid secretion. The multidrug resistant protein 4 is expressed in the apical membrane of the renal tubular epithelial cells, which transfers uric acid from the renal tubular epithelial cells into the renal tubular lumen. The urate-anion transporter 1 as well as the organic anion transporters 1 and 3 are all the organic anion transporters belonging to the SLC22 A family of transmembrane transporters, and all participate in the uric acid transport in the kidney, especially the uric acid secretion and excretion. In this review, we summarize the research progress of these uric acid transporters, focusing on their effects on the regulation of the serum uric acid balance.
