Soluble guanylate cyclase stimulators:research advances
10.13220/j.cnki.jipr.2018.08.003
- VernacularTitle:可溶性鸟苷酸环化酶刺激剂的研究进展
- Author:
Chun-Yu LIN
1
;
Zhi-Bing ZHENG
;
Xian JIA
;
Song LI
Author Information
1. 沈阳药科大学制药工程学院
- Keywords:
nitric oxide;
soluble guanylate cyclase (sGC);
sGC stimulators
- From:
Journal of International Pharmaceutical Research
2018;45(8):575-581
- CountryChina
- Language:Chinese
-
Abstract:
The soluble guanylate cyclase (s GC) is a key signal transduction enzyme in the nitric oxide (NO) -sGC-cyclic guanosine monophosphate (cGMP) pathway, which can be activated by NO and thus catalyzes the conversion of guanosine triphosphate (GTP) into the c GMP. As a second messenger, cGMP modulates the activity of downstream effectors, including the cGMP-dependent protein kinases (cGK), cGMP-dependent phosphodiesterases (PDE) and ion-gated channels, and ultimately participates in the regulation of several physiological functions, including the function of cardiovascular, gastrointestinal and central nervous systems. sGC stimulators could not only directly stimulate s GC but also synergistically act with NO to increase the sGC enzyme activity, which has shown a great potential to treat various diseases via regulating the NO-s GC-cGMP signaling pathway. Here, we give an overview of NOindependent sGC stimulators in clinical trial.