Mechanism of metabolic surgery mediated FGF21 in improving insulin resistance
10.3760/cma.j.issn.1673-4203.2019.04.010
- VernacularTitle:代谢手术介导FGF21改善胰岛素抵抗的机制进展
- Author:
He WANG
1
;
Jing YANG
;
Xueying SHANG
;
Na AO
;
Shi JIN
;
Jian DU
Author Information
1. 中国医科大学附属第四医院内分泌代谢内科
- Keywords:
FGF21;
Obesity;
Metabolic surger;
Insulin resistance
- From:
International Journal of Surgery
2019;46(4):261-265
- CountryChina
- Language:Chinese
-
Abstract:
Insulin resistance refers to a decrease in the physiological utilization of normal concentrations of insulin by target organs such as liver and adipose tissue.Insulin resistance is central to a variety of metabolic diseases caused by obesity.FGF21 is a novel regulator of glycolipid metabolism,which has the effects of improving insulin resistance,reducing body weight,regulating blood lipids,promoting fatty acid oxidation,and increasing energy consumption.Metabolic surgery is effective in the treatment of obesity and insulin resistance,and the level of FGF21 changes after surgery.This article will review the possible mechanisms of metabolic surgery to mediate FGF21 to improve insulin resistance.
