Research progress in stimuli-responsive mesoporous silica nano drug delivery systems for tumor therapy
10.3760/cma.j.issn.1673-4181.2019.01.012
- VernacularTitle:刺激响应型介孔硅纳米药物递送系统在肿瘤治疗中的研究进展
- Author:
Chenlu HUANG
1
;
Dunwan ZHU
;
Linhua ZHANG
Author Information
1. 中国医学科学院北京协和医学院生物医学工程研究所
- Keywords:
Mesoporous silica nanoparticles;
Stimuli-responsive;
Controlled release;
Tumor therapy
- From:
International Journal of Biomedical Engineering
2019;42(1):66-70
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, mesoporous silica nanoparticles (MSNs) have been widely used in the construction of various intelligent drug delivery systems due to their unique and excellent properties. The stimuli-responsive drug delivery system based on mesoporous silica nanoparticles can effectively load anticancer drugs and target them to tumor cells, and then responsively release anticancer drugs under the action of specific stimulation signals. The method of specifically delivering anticancer drugs to target sites not only can greatly improvethe drug efficacy, but also effectively reduce the side effects of anticancer drugs on normal tissues and organs. Thereby the advantages of anticancer drugs in tumor therapy are improved. In this paper, the applications and developments of stimuliresponsive mesoporous silica nano drug delivery systems in tumor therapy were summarized.
