Research progress in pH/redox dual sensitive nano-carrier system
10.3760/cma.j.issn.1673-4181.2019.01.011
- VernacularTitle:pH/还原双敏感性纳米载药系统的研究进展
- Author:
Zhiming ZHANG
1
;
Chenlu HUANG
;
Linhua ZHANG
;
Dunwan ZHU
Author Information
1. 中国医学科学院北京协和医学院生物医学工程研究所
- Keywords:
Tumor;
pH/redox sensitive;
Nano-drug loading
- From:
International Journal of Biomedical Engineering
2019;42(1):59-65
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors are the second most important cause of death after cardiovascular and cerebrovascular diseases. Chemotherapeutic drugs for tumor treatment have strong toxic side effects. The common solution is to use nanoparticle as a carrier that can deliver drugs to tumor issues so as to kill the tumor cells. However, most of the current drug-carriers have a serious drug loss before reaching the tumor area, which makes the difficult control of drug release. Multi-stimulus responsive nano-carrier systems can overcome these drawbacks and make drug release controllable. pH/redox dual sensitive nano-carrier systems are currently hot research direction. In this paper, the research progress of pH/redox dual sensitive nano-carrier systems in recent years was reviewed in order to provide reference for relative researches.
