Correlation between serum miR-320b and carotid atherosclerosis in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.02.005
- VernacularTitle:血清miR-320b与急性缺血性卒中患者颈动脉粥样硬化的相关性
- Author:
Jiang XU
1
;
Zixuan CHEN
;
Yingge WANG
;
Zuowei DUAN
;
Xiangming TANG
;
Tingting YUAN
;
Yaoyao LU
;
Hongmei CHEN
;
Kunning YAN
;
Jingyan LIANG
;
Xinjiang ZHANG
Author Information
1. 扬州大学医学院 225009
- Keywords:
Stroke;
Brain ischemia;
Carotid artery diseases;
Plaque,atherosclerotic;
MicroRNAs;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2019;27(2):113-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum miR-320b and carotid atherosclerosis in patients with acute ischemic stroke.Methods From January 2017 to December 2017,patients with acute ischemic stroke visited the Department of Neurology,the Affiliated Hospital of Yangzhou University were enrolled.According to the findings of carotid artery ultrasonography,they were divided into plaque group and plaque-free group.The baseline clinical data such as demographic data,vascular risk factors,and blood biochemical indicators were collected.Reverse transcription quantitative polymerase chain reaction was used to detect the expression level of serum miR-320b.Multivariatelogistic regression analysis was used to determine the independent risk factors for carotid atherosclerosis.Results A total of 135 patients with acute ischemic stroke were enrolled in this study,including 58 females and 77 males,aged 58.4 ± 10.6 years.There were 85 patients in the plaque group and 50 in the plaque-free group.The total cholesterol (t =5.523,P =0.023) and low-density lipoprotein cholesterol (t =4.415,P =0.044) in the plaque group were significantly higher than those in the plaque-free group,while high-density lipoprotein cholesterol (t =5.849,P=0.017) and serum miR-320b (t =4.331,P=0.039) were significantly lower than those in the plaque-free group.Multivariate logistic regression analysis showed that referring to the highest quartile group,the low serum miR-320b level might be an independent risk factor for carotid atherosclerosis (the first quartile group:odds ratio 2.701,95％ confidence interval 1.154-6.321,P =0.022;the second quartile group:odds ratio 2.521,95％ confidence interval 1.249-5.091,P =0.010;and the third quartile group:odds ratio 1.849,95％ confidence interval 1.041-3.283,P=0.036).Conclusion The low serum miR-320b level might be an independent risk factor for carotid atherosclerosis in patients with acute ischemic stroke.
