Roles of sphingosine 1-phosphate in ischemic stroke: a potential therapeutic target for neuroprotection
10.3760/cma.j.issn.1673-4165.2019.01.009
- VernacularTitle:1-磷酸鞘氨醇在缺血性卒中中的作用:潜在的神经保护治疗靶点
- Author:
Yuanbo CAO
1
;
Jia LIU
;
Hui ZHU
;
Yan LIU
;
Xue WANG
;
Tianren JIA
;
Guojun TAN
Author Information
1. 河北医科大学第二医院神经内科
- Keywords:
Stroke;
Brain ischemia;
Sphingosine;
Receptors,lysosphingolipid;
Sphingosine 1-phosphate;
Sphingosine kinase;
Inflammation;
Fingolimod hydrochloride;
Neuroprotective agents
- From:
International Journal of Cerebrovascular Diseases
2019;27(1):50-56
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is one of the most important causes of death and disability in humans,but the effective methods for treating brain injury after stroke are quite limited.Sphingosine 1-phosphate (S1P) is a pleiotropic lipid.There is certain interdependence between its metabolism and regulation and the molecular mechanisms involved in important biological events following cerebral ischemia.Membrane lipid therapy with S1P as the core may be an effective neuroprotective strategy of ischemic stroke.
