The research progress of soluble fibrinogen-like protein 2
10.3969/j.issn.1673-4130.2019.04.022
- VernacularTitle:可溶性纤维蛋白原2的研究进展
- Author:
Shenglan MENG
1
;
Chuangqing XIAO
Author Information
1. 湖南师范大学第二附属医院检验科
- Keywords:
soluble fibrinogen-like protein 2;
Tregs cells;
research progress
- From:
International Journal of Laboratory Medicine
2019;40(4):468-471,507
- CountryChina
- Language:Chinese
-
Abstract:
Soluble fibrinogen-like protein 2 (sFGL2) , is an novel effector secreted by the CD4+CD25+CD127lowTregs cells and plays an important role in immunoregulation.It is critical for the maintenance of the activity and function of Tregs.It can induce the apoptosis of B cells, suppress the maturation of dendritic cells and suppress the activation and proliferation of T cells through the FcγRⅡB receptor.This review concluded the recent progress of the genes, structure, immunoregulatory effects of sFGL2, and discussed the clinical implications of sFGL2in hepatitis, autoimmunity, transplantation, tumors and atherosclerosis.
