Research progress of combined rheumatoid factor ANCA, IL-1, IL-6, TNF-αdetection in diagnosing rheumatoid arthritis
10.3969/j.issn.1673-4130.2019.04.018
- VernacularTitle:ANCA、IL-1、IL-6、TNF-α四项检测诊断类风湿性关节炎的研究进展
- Author:
Biying SHU
1
;
Qijun JIANG
;
Feng CAI
Author Information
1. 上海中医药大学附属市中医医院检验科
- Keywords:
rheumatoid arthritis;
antineutrophil cytoplasmic antibody;
interleukin;
tumor necrosis factor-α;
integrated traditional Chinese and Western medicine
- From:
International Journal of Laboratory Medicine
2019;40(4):448-452
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid Arthritis is a kind of chronic autoimmune diseases mainly involving joint, which is characterized by systemic inflammatory response.Studies have shown that Rheumatoid arthritis patients showed associated antineutrophil cytoplasmic antibody (ANCA) and inflammatory cytokines such as interleukin (IL) , tumor necrosis factor (TNF) increased, the positive of ANCA and the increase of IL-1, IL-6, TNF-αare especially seen in the Rheumatoid arthritis patients who have inflammatory reaction, and which are roughly equal to the articular synovitis pathological mechanism of wind dampmess heat accumulation pattern in the traditional Chinese medicine.The treatment for Rheumatoid arthritis patients, Western treatment is use the methotrexate (MTX) as basic drugs, combined with other drugs to control the positive of ANCA and the higher of IL-1, IL-6, TNF-α.And combining traditional Chinese medicine treatment, the effect is not only at to increase Western effection but also be able to reduce the side effects of Western medicine.Therefore, the research of combined rheumatoid factor ANCA, IL-1, IL-6, TNF-αdetection is benefit to diagnosing rheumatoid arthritis.
