Significance of hemoglobin H detection in the diagnosis of α-thalassemia and MDS
10.3969/j.issn.1673-4130.2019.04.014
- VernacularTitle:血红蛋白H检测在α-珠蛋白生成障碍性贫血和MDS诊断中旳意义
- Author:
Xue SUN
1
;
LiJin BO
;
Yan XU
;
YuPing ZHAO
Author Information
1. 中国医学科学院北京协和医学院血液病医院/血液学研究所检测中心
- Keywords:
hemoglobin H;
alpha thalassemia;
myelodysplastic syndrome
- From:
International Journal of Laboratory Medicine
2019;40(4):435-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of hemoglobin H in the diagnosis of alpha thalassemia and Myelodysplastic syndrome. Methods A retrospective analysis of the complete clinical data of hemoglobin H in our hospital from January 2007 to October 2017 was performed. The hemoglobin H content in 34 cases of alpha thalassemia and the corresponding blood routine, reticulocyte, Bilirubin, and plasma free hemoglobin levels were analyzed by Pearson correlation. Results 39 cases of hemoglobin H positive cases, of which 34 cases diagnosed as alpha thalassemia,5 cases diagnosed as myelodysplastic syndrome; for alpha thalassemia, hemoglobin H content and reticulocyte, plasma free hemoglobin and Indirect bilirubin test results are related(r =0. 453 ,0. 398,0. 412,P<0. 05). Conclusion Hemoglobin H is not only found in alpha thalassemia but detected in other types of hematologic disorders.
