Performance evaluation for detecting total bilirubin in neonatal cerebrospinal fluid
10.3969/j.issn.1673-4130.2019.04.001
- VernacularTitle:新生儿脑脊液总胆红素测定的性能评价
- Author:
Fei LIU
1
;
Xiantao QIU
;
Xiaojuan CHEN
;
Minmin CAI
;
Qingling MA
;
Shuyin PANG
;
Haiying LIU
Author Information
1. 广州市妇女儿童医疗中心检验部
- Keywords:
neonatal;
cerebrospinal fluid;
total bilirubin;
performance evalution
- From:
International Journal of Laboratory Medicine
2019;40(4):385-387,391
- CountryChina
- Language:Chinese
-
Abstract:
Objective Newborn bilirubin encephalopathy seriously threatens the life and health of newborns, Both the mortality and morbidity are high.Cerebrospinal fluid bilirubin concentration can better reflect the blood-brain barrier function and brain bilirubin levels, which can help the diagnosis of bilirubin encephalopathy.Methods In order to meet the clinical needs, we confirmed the detection performance of the existing serum bilirubin detection system for cerebrospinal fluid bilirubin, including precision, accuracy and analysis of measurement range.Results The results showed that the detection system was linear at 1.0-25.1μmol/L, and the daytime CVat normal and pathological values was less than the precision requirement (6％) .The bias of each sample and the average bias are less than the allowable bias (5％) , the total error is less than the total allowable error (15％) .Conclusion Therefore, the performance of the detection system meet the industry standards, can be used for neonatal cerebrospinal fluid bilirubin detection.
