Research of B7-H3 and carcinoembryonic antigen on diagnosing malignant pleural effusion
10.3969/j.issn.1673-4130.2019.03.003
- VernacularTitle:B7-H3和癌胚抗原在恶性胸腔积液中的检测及临床意义
- Author:
Qiongying HU
1
;
Jianrong LUO
;
Chengjin AI
;
Gaoli CHEN
;
Chaoming ZHANG
;
Daqian XIONG
Author Information
1. 成都中医药大学附属医院检验科
- Keywords:
Malignant pleural effusion;
Benign pleural effusion;
B7-H3;
Carcinoembryonic antigen
- From:
International Journal of Laboratory Medicine
2019;40(3):266-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of B7-H3 and carcinoembryonic antigen (CEA) on diagnosis of malignant pleural effusion (MPE).Methods We collected and analysed the expression of B7-H3 and CEA in 40 MPE cases and 22 cases of benign pleural effusion (BPE) using enzyme-linked immunosorbent assay (ELISA).Receiver operator characteristic curves (ROC) were drawn according to the expression of B7-H3 and CEA, calculated diagnosis sensitivity, specificity and the area under curve (AUC).Results The diagnosis sensitivity of B7-H3 was 62.5％, specificity 81.0％, with the AUC of 0.777;similarly, The diagnosis sensitivity of CEA was 72.5％, specificity 81.0％, with the AUC of 0.850.Higher AUC of 0.910 was gained in combination ROC, with sensitivity and specificity of 72.5％, 81.0％, respectively.Conclusion B7-H3 and CEA could be available diagnosing markers for MPE.Combined applications of B7-H3 and CEA have higher AUC.They may be widely applied in future clinical practice.
