Gastroenteropancreatic Neuroendocrine Tumors with Liver Metastases in Korea: A Clinicopathological Analysis of 72 Cases in a Single Institute.
- Author:
Yooju SHIN
1
;
Sang Yun HA
;
Jiyeon HYEON
;
Boram LEE
;
Jeeyun LEE
;
Kee Taek JANG
;
Kyoung Mee KIM
;
Young Suk PARK
;
Cheol Keun PARK
Author Information
- Publication Type:Original Article
- Keywords: Liver; Metastasis; Neuroendocrine tumor; Pathology; Prognosis
- MeSH: Follow-Up Studies; Humans; Korea*; Liver*; Medical Records; Multivariate Analysis; Neoplasm Metastasis*; Neoplasms, Unknown Primary; Neuroendocrine Tumors*; Pancreas; Pathology; Prognosis; Rectum; Stomach; Survivors; Urinary Bladder
- From:Cancer Research and Treatment 2015;47(4):738-746
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Management of gastroenteropancreatic (GEP) neuroendocrine tumors with liver metastases (NETLM) presents many clinical challenges. Assessment of the extent of disease and primary tumor site is crucial for management. In this study, we investigated the primary tumor sites and prognostic factors in GEP NETLM among Korean patients. MATERIALS AND METHODS: We reviewed the medical records of 72 Korean patients diagnosed with GEP NETLM between January 1999 and May 2013, focusing on their clinical and pathologic characteristics. RESULTS: The most frequently encountered primary tumor sites were the pancreas (n=25, 35%), stomach (n=8, 11%), gall bladder (n=4, 6%) and rectum (n=3, 4%). Twenty-five patients (35%) had occult primary tumor. Twelve patients (17%) had histological grade G1 tumors, 30 patients (42%) had G2 tumors, and 30 patients (42%) had G3 tumors. The mean follow-up period after histological confirmation of hepatic metastases was 11.30+/-2.44 months for G3 tumors, 19.67+/-4.09 months for G2 tumors, and 30.67+/-6.51 months for G1 tumors. Multivariate analyses revealed that an unknown primary tumor site (p=0.001) and higher histological grade (p < 0.001) were independent prognostic indicators for shorter overall survival (OS). Most long-term survivors (OS > 24 months) had received antitumor treatment. CONCLUSION: The primary tumor site most frequently associated with GEP NETLM was the pancreas. Unknown primary tumor and higher histological grade were independent prognostic indicators for shorter OS. Patients identified as being at a risk of shorter OS should be followed up closely.
