Value of serum uric acid and brain natriuretic peptide in the evaluation of progressive ischemic stroke
10.3969/j.issn.1673-4130.2019.02.018
- VernacularTitle:血尿酸和脑钠肽水平评估进展性缺血性脑卒中的价值分析
- Author:
Qian MENG
1
;
Shan XU
;
Linlin XIAO
;
Hu XIAO
Author Information
1. 上海交通大学附属第六人民医院南院检验科
- Keywords:
serum uric acid;
brain natriuretic peptide;
progressive ischemic stroke;
combined detection
- From:
International Journal of Laboratory Medicine
2019;40(2):196-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum uric acid and brain natriuretic peptide in the evaluation of progressive ischemic stroke.Methods Totally 63cases of progressive ischemic stroke patients in our hospital from October 2016to October 2017were selected as the observation group.According to the severity of the disease, the patients were divided into mild group[National Institute of Health Stroke Scale (NIHSS) score＜7], medium group (NIHSS score 7-15) and severe (NIHSS score＞15).Meanwhile, 60cases of nonprogressive ischemic stroke patients in the hospital from January 2014and December 2016were selected as the control group.After admission, 3 mL fasting peripheral venous blood was collected in each subject in both groups, and the serum was isolated.Enzyme-linked immunosorbent assay (ELISA) was used to determine the level of brain natriuretic peptide and uric acid/eroxidase coupling method was used to determine the level of serum uric acid.Results The levels of serum uric acid and brain natriuretic peptide were significantly higher than those of the control group (P＜0.05).The levels of natriuretic peptide and serum uric acid in severe group were significantly higher than those of mild group and medium group, and the levels of two indicators in medium group were significantly higher than those of mild group (P＜0.05).In addition, the sensitivity and specificity of combined detection were significantly higher than the single index detection of serum uric acid and brain natriuretic peptid (P＜0.05).Conclusion The combined detection of serum uric acid and brain natriuretic peptide have higher sensitivity and specificity.
