Expression and significance of serum INHB, IGF-1, VEGF and E2 in patients with polycystic ovary syndrome
10.3969/j.issn.1673-4130.2019.02.014
- VernacularTitle:血清INHB、IGF-1、VEGF、E2在多囊卵巢综合征患者中的表达及临床意义
- Author:
Shu SHEN
1
;
Xiaoyan ZHOU
;
Henggui HU
;
Kao MENG
Author Information
1. 宿州市皖北煤电集团总医院生殖科
- Keywords:
polycystic ovary syndrome;
serum inhibin B;
insulin-like growth factor 1;
vascular endothelial growth factor;
estradiol
- From:
International Journal of Laboratory Medicine
2019;40(2):181-183,187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of serum inhibin B (INHB), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF) and estradiol (E2) in patients with polycystic ovary syndrome (PCOS).Methods A total of 45patients with PCOS in the hospital from April 2015to May 2016, were selected as observation group.In addition, 45healthy women who underwent physical examination due to male infertility were selected as control group.The significance and diagnostic value of serum INHB, IGF-1, VEGF and E2in PCOS were analyzed.Results The levels of serum INHB, IGF-1, VEGF and E2in observation group were significantly higher than those of control group (P＜0.05).The receiver operating characteristic curve (ROC curve) analysis showed that the AUC of INHB, IGF-1, VEGF and E2were 0.935, 0.988, 0.992and 0.759, respectively.The sensitivity of PCOS were 80.93％, 81.18％, 79.12％and79.07％, while the specificity of PCOS were 73.05％, 75.17％, 77.49％and 78.59％, respectively.ConclusionSerum INHB, IGF-1, VEGF and E2are highly expressed in patients with PCOS, which can be used as an important indicators in the diagnosis of PCOS.
