Research progress of relationship between GATA family gene mutations with congenital heart diseases
10.3760/cma.j.issn.1673-4408.2019.03.012
- VernacularTitle:GATA家族基因突变与先天性心脏病的研究进展
- Author:
Mingxi CHEN
1
Author Information
1. 内蒙古自治区人民医院儿科
- Keywords:
GATA transcription factor;
Congenital heart disease;
Gene mutation
- From:
International Journal of Pediatrics
2019;46(3):194-197
- CountryChina
- Language:Chinese
-
Abstract:
The GATA transcription factor family is a type of transcription regulatory factors containing zinc finger structure,in which GATA4,GATA5 and GATA6 play a key role in the process of heart development and functional maturity.A large number of studies have confirmed that the GATA transcription factor family is not only involved in the the heart development,but also its mutations are related to the occurrence of human congenital heart diseases (CHD).This article mainly reviews the relationship between GATA family with heart development,and the relationship between GATA family gene mutation with congenital heart diseases.
