Progress of human milk oligosaccharides and infant-related diseases
10.3760/cma.j.issn.1673-4408.2019.02.012
- VernacularTitle:母乳低聚糖与婴幼儿相关疾病研究进展
- Author:
Yinying YANG
1
;
Hao LI
;
Jiayu WU
Author Information
1. 扬州大学医学院附属医院江苏省苏北人民医院新生儿科
- Keywords:
Human milk oligosaccharides;
Prebiotics;
Antiadhesives;
Modulators of cell responses
- From:
International Journal of Pediatrics
2019;46(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
Human milk oligosaccharides (HMOs) are the third largest solid component in human milk,followed by lactose and lipids.The importance of HMOs to infants has attracted more and more attention.The core structure of HMOs consists of galactose (Gal),glucose (Glc),N-acetylglucosamine (GlcAc),fucose (Fuc) and sialic acid (Sia) derived N-acetylneuraminic acid (Neu5Ac),which link with different groups that have different effects.HMOs could be used as prebiotics to regulate intestinal flora,as antiadhesives to resist pathogen adhesion,and as modulators of cell responses to regulate cellular inflammation.Through the mechanisms above,HMOs can affect many aspects of infant growth and development,such as relieving diarrhea,preventing respiratory infections,alleviating allergies,interfering with obesity,and even affecting the acquired immunodeficiency syndrome.This article will explain the structure of HMOs,the metabolism inside human body and the definite mechanism of action in process of infantile development and describe some related diseases.
