Analysis of Genetic Polymorphism and Genetic Distance of 19 Autosomal STR Loci in Jiangsu Han Population
- VernacularTitle:江苏汉族人群19个常染色体STR基因座基因多态性及遗传距离分析
- Author:
Meng PAN
1
;
He CUI
;
Xiao-Bin JU
;
Yan-Ting LIU
;
Qin YE
;
Zi-Qing CHEN
;
Xiao-Jian DING
;
Qi CHEN
;
Rong ZHOU
;
Min GU
;
Hui-Ying ZHOU
Author Information
1. 南京医科大学第一附属医院 江苏省人民医院司法鉴定所
- Keywords:
forensic genetics;
polymorphism,genetic;
short tandem repeat;
genetic distance;
Han nationality;
Jiangsu
- From:
Journal of Forensic Medicine
2018;34(6):650-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of alleles in 19 autosomal short tandem repeat (STR) loci in Jiangsu Han population.Methods Goldeneye20A kit was used to detect 9 025 samples.Genetic analysis was performed on typing data of 19 autosomal STR loci, and genetic distance with other 17 populations was analyzed.Results All the 19 autosomal STR loci were consistent with the Hardy-Weinberg equilibrium (P＞0.05), with the heterozygosity 0.616 1-0.916 3, probability of match 0.012 8-0.202 6, discrimination power 0.797 4-0.987 2, probability of paternity exclusion 0.310 8-0.828 8, and polymorphic information content 0.561 7-0.913 6.The cumulative discrimination power and cumulative probability of exclusion were 0.999 999 999 999 999 998 434 1 and 0.999 999 989, respectively.The Jiangsu Han population had close genetic distances with the Han population in Tianjin, Hunan and Jilin, and significant difference with Han population in Aletai region in Xinjiang (P＜0.05).Conclusion The STR allele polymorphism data and population genetic parameters of Jiangsu Han population can provide data support for the forensic application of these STR loci in Jiangsu Han population.
