Retention Time of Four Common Poisons (Drugs) by GC-MS Qualitative Analysis
- VernacularTitle:4种常见毒(药)物GC-MS定性分析的保留时间
- Author:
Shao-Dan LIU
1
;
Tao MIN
;
Mei WANG
;
Da-Ming ZHANG
Author Information
1. 山西医科大学法医学院
- Keywords:
forensic toxicology;
retention time;
gas chromatography-mass spectrometry;
dichlorvos;
phorate;
diazepam;
estazolam
- From:
Journal of Forensic Medicine
2018;34(6):595-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the maximum allowable deviation of retention time (RT) or relative retention time (RRT) between the common poisons (drugs) and standard solvent by gas chromatography-mass spectrometry (GC-MS).Methods After pretreatment with liquid-liquid extraction, four common poisons (drugs) —dichlorvos, phorate, diazepam and estazolam—were detected by full scan mode GC-MS.RT and RRT were analyzed according to combined uncertainty and expanded uncertainty. Results The expanded uncertainty of RT and RRT were 6.0× lO-4-14.1×l0-3 and 2.5 ×l0-6-5.9× lO-5 (k=3), respectively.The RT of poisons (drugs) was relatively stable in blood samples with different mass concentrations.Among dichlorvos, phorate, diazepam and estazolam, the absolute deviation and relative deviation of RT were≤0.03 min and≤0.4％, respectively, and those of RRT were≤0.003 min and≤0.3％, respectively.Conclusion The maximum allowable deviations of RT and RRT for common poisons (drugs) in blood samples are recommended to be±0.05 min and±0.5％.
