Effects of scoparone on the expression of RORγt and related factors in experimental allergic rhinitis rats
10.16066/j.1672-7002.2019.02.007
- VernacularTitle:滨蒿内酯对实验性变应性鼻炎大鼠维甲酸相关孤儿核受体γt及相关因子表达的影响
- Author:
Zhen WANG
1
;
Lilan CHENG
;
Shifu ZHANG
;
Gengtian LIANG
Author Information
1. 武汉大学附属同仁医院(武汉市第三医院)耳鼻咽喉科
- Keywords:
Rhinitis,Allergic,Perennial;
Rhinitis,Allergic,Seasonal;
Orphan Nuclear Receptors;
Interleukin-17;
Interleukin-23;
scoparone
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2019;26(2):84-87
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effects of behavior, pathology, the serum IL-17, IL-23 level, and the expressing of RORγt, IL-17 and IL-23 mRNA in nasal tissues of experimental allergic rhinitis rats after the scoparone treatment. METHODS The animal model were divided into 4 groups: normal control group(group NC), allergic rhinitis group(group AR), artemolactone group(group Sco) and dexamethasone group(group Dxm). The symptom score, HE staining of the nasal mucosa, IL-17 and IL-23 level in serum measured by ELISA, the RORγt, IL-17 and IL-23 mRNA level detected by RTPCR. RESULTS Symptoms and inflammatory pathology were relieved in the experimental group after scoparone treatment. The serum levels of the IL-17, IL-23 in group Sco and group Dxm were little higher than that in group NC. The levels of RORγt, IL-17 and IL-23 mRNA in group AR were significantly higher than that in the other three groups. The levels of RORγt, IL-17 and IL-23 mRNA in group Sco and group Dxm were little higher than that in the group NC. CONCLUSION Sco could significantly inhibited or eliminated the allergy symptoms of AR in rats, and could reduce the severity and inflammatory response of diseases.
