Progress of gene mutation patterns and targeted therapy in myelodysplastic syndromes
10.3760/cma.j.issn.1009-9921.2019.03.002
- VernacularTitle:骨髓增生异常综合征基因突变模式及靶向治疗研究进展
- Author:
Yubin DING
1
;
Yufeng TANG
;
Xudong TANG
Author Information
1. 中国中医科学院西苑医院血液科
- Keywords:
Myelodysplastic syndromes;
Mutation;
Targeted therapy
- From:
Journal of Leukemia & Lymphoma
2019;28(3):132-136
- CountryChina
- Language:Chinese
-
Abstract:
The myelodysplastic syndromes (MDS) are collectively the most common myeloid neoplasms,and the clonal hematopoiesis presented in MDS results in bone marrow failure.An understanding of the MDS gene mutation profile can help to understand the biological significance of MDS and can be used for early diagnosis of disease,precise risk stratification,interpretation of pathogenesis,and improvement of treatment options.As the pathological features of MDS are gradually elucidated,individualized and effective treatment options are improved,and the targeted drug therapy may improve the prognosis of MDS patients.This article introduces the progress of MDS gene mutations and targeted therapy in the 60th American Society of Hematology (ASH) Annual Meeting.
