Clinical significances of additional chromosome abnormalities and t (15;17) in acute promyelocytic leukemia
10.3760/cma.j.issn.1009-9921.2019.02.010
- VernacularTitle:急性早幼粒细胞白血病附加染色体异常及t(15;17)的临床意义
- Author:
Yingying LIU
1
;
Tingting FU
;
Chunting ZHAO
;
Boli CUI
;
Lingjie SUN
;
Zhan SU
;
Xiaodan LIU
;
Tianlan LI
Author Information
1. 青岛大学附属医院血液内科 266000
- Keywords:
Leukemia,promyelocytic,acute;
Chromosome aberrations;
Additional chromosome abnormalities;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2019;28(2):100-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significances of additional chromosome abnormalities and t(15;17) in acute promyelocytic leukemia (APL). Methods A total of 90 newly diagnosed APL patients in the Affiliated Hospital of Qingdao University from January 2007 to June 2014 were analyzed retrospectively. Patients with different chromosome karyotypes were divided into four groups: additional chromosome number abnormalities group (16 cases), additional chromosome structural abnormalities group (14 cases), additional chromosome number and structural abnormalities group (4 cases) and typical chromosome group (56 cases). According to whether the patient contained t(15;17), the patients were divided into group with t (15;17) and group without t (15;17). The short-term efficacy and survival of each group were analyzed and compared. Results The rate of complete remission in additional chromosome number abnormalities group, additional chromosome structural abnormalities group, additional chromosome number and structural abnormalities group and typical t(15;17) chromosome changes group were 56.3％(9/16), 100.0％(14/14), 25.0％(1/4) and 82.1％(46/56), the early mortality rates were 25.0％(4/16), 0 (0/14), 75.0％(3/4) and 8.9％ (5/56) respectively. Among them, the additional number and structural abnormalities group had lower complete remission rate and higher early mortality rate, and compared with other groups, the differences were statistically significant (all P< 0.05). The complete remission rates of the group with t (15;17) and the group without t (15;17) were 80.5％ (66/82) and 50.0％ (4/8), respectively, and the difference was not statistically significant (P= 0.070). Conclusions APL patients with karyotypes with additional number and structural changes have low complete remission rate, high early mortality rate and poor prognosis. Patients with t(15;17)have a high rate of complete remission.
