Chronic myelogenous leukemia combined with solid malignant neoplasms: report of eight cases and review of literature
10.3760/cma.j.issn.1009-9921.2019.02.009
- VernacularTitle:慢性粒细胞白血病合并恶性实体瘤八例并文献复习
- Author:
Xiaojiao WANG
1
;
Ruihua MI
;
Lin CHEN
;
Jinxiao YAO
;
Ruyu YANG
;
Haiping YANG
;
Junjie YIN
;
Xudong WEI
Author Information
1. 郑州大学附属肿瘤医院中心实验室 450008
- Keywords:
Leukemia,myelogenous,chronic;
Neoplasms,multiple primary;
Treatment;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2019;28(2):96-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features of chronic myelogenous leukemia (CML) combined with solid malignant neoplasms. Methods The clinical data of 8 CML patients with solid malignant neoplasms who were admitted to the Affiliated Tumor Hospital of Zhengzhou University, the Central Hospital of Nanyang City, the First Affiliated Hospital of Science and Technology University of Henan, and the Central Hospital of Xinxiang City from August 2006 to August 2018 were analyzed retrospectively. The clinical features, treatment and prognosis of the patients were summarized with the review of literature. Results Among the 8 patients, 3 were male and 5 female, aged 40-76 years, with a median of 50 years old. Seven cases were in CML chronic phase, and 1 was in accelerated phase. Seven patients were treated with tyrosine kinase inhibitor (TKI), and only 1 patient was treated with hydroxyurea. In 8 patients, two cases presented with synchronous multiple primary cancer (SMPC), 6 cases presented with heterochrony multiple primary cancer (HMPC). two patients received the operation, 1 patient received the operation and chemotherapy, 4 patients received chemotherapy, and 1 patient received the isotope treatment. One SMPC patient died and another one was under treatment, and 6 HMPC patients were under treatment. ConclusionsThe relationship between CML and solid malignant neoplasm is under discussion, but patients with CML and solid malignant neoplasm are not unusual. Clinicians should raise awareness to avoid misdiagnosis. The treatment should follow the two main lines that are comprehensive treatment and individualized treatment.
