Study on mitochondrial DNA mutation in patients with primary multiple myeloma
10.3760/cma.j.issn.1009-9921.2019.02.007
- VernacularTitle:初发多发性骨髓瘤患者线粒体DNA突变情况研究
- Author:
Jing WANG
1
;
Yongan ZHOU
;
Liping SU
;
Fengmin LI
;
Ming CHEN
Author Information
1. 河北省秦皇岛市第一医院血液科 066000
- Keywords:
Multiple myeloma;
Mitochondrial;
DNA mutation
- From:
Journal of Leukemia & Lymphoma
2019;28(2):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mitochondrial DNA mutation in patients with primary multiple myeloma. Methods The mitochondrial DNA of 5 patients with primary multiple myeloma in the First Hospital of Qinhuangdao from February to June 2017 were amplified by polymerase chain reaction (PCR) and sequenced directly, and the results were compared with revised Cambridge Reference Sequence (rCRS) and Human Mitochondrial Gene Database (mtDB) database. Results There were 42 mutation genes, with 52.38％(22/42) mutation genes in D-loop region, 9.52％(4/42) mutation genes in ND4L region, 2.38％(1/42) mutation genes in ND5 region, 26.19％ (11/42) mutation genes in Cytb region, 7.14％ (3/42) mutation genes in ND1 region, and 4.76％ (2/42) mutation genes in COⅡ region. Conclusion There is a high mitochondrial DNA mutation rate in patients with primary multiple myeloma.
