Expressions of SENP1, SENP2 and SENP6 proteins in human glioma tissue and cells and their mechanisms
- VernacularTitle:SENP1、SENP2和SENP6蛋白在人恶性胶质瘤组织和细胞中的表达及其意义
- Author:
Dongdong WANG
1
;
Yu ZHANG
;
Weiqi ZHANG
;
Zhendong DING
;
Hongquan YU
;
Ling QI
Author Information
1. 吉林大学第一医院神经外科
- Keywords:
SUMO-special proteases;
malignant glioma;
LN443 cell;
U343 cell
- From:
Journal of Jilin University(Medicine Edition)
2019;45(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expressions of SENP1, SENP2and SENP6proteins in human malignant glioma tissue and cells, and to elucidate the their effects in the development of malignant glioma.Methods:The samples of normal human brain tissue and malignant glioma tissue were obtained and used as normal control group and malignant glioma group, respectively.The Cos7cells and the malignant glioma LN443and U343cells were cultured;the Cos7cells were used as normal cell control group, and the LN443and U343cells as malignant glioma cell group.Western blotting method was used to detect the expression levels of SENP1, SENP2and SENP6proteins in human malignant glioma tissue and cells.Results:In brain tissue, the expression levels of SENP1, SENP2and SENP6proteins in malignant glioma group were higher than those in normal control group (P＜0.05) .Compared with normal cell control group, the expression levels of SENP1, SENP2and SENP6proteins in the LN443and U343cells in malignant glioma cell group were significantly increased (P＜0.05) .Conclusion:SENP1, SENP2and SENP6proteins highly express in the malignant glioma tissue and cells, and they may play an important role in promoting the occurrence of malignant glioma.
