Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression
10.3349/ymj.2019.60.4.319
- Author:
Xiaohuan TANG
1
;
Xiaofang QIAO
;
Chao CHEN
;
Yuanda LIU
;
Jiaming ZHU
;
Jingjing LIU
Author Information
1. Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, China. Zhujiaming75@sina.com, jingjingstarone@163.com
- Publication Type:Review
- Keywords:
Colorectal cancer;
lncRNA;
signaling pathway
- MeSH:
Biological Processes;
Biomarkers;
Colon;
Colonic Neoplasms;
Colorectal Neoplasms;
Neoplasm Metastasis;
Prognosis;
Recurrence;
RNA, Long Noncoding;
RNA, Untranslated
- From:Yonsei Medical Journal
2019;60(4):319-325
- CountryRepublic of Korea
- Language:English
-
Abstract:
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and its high rates of relapse and metastasis are associated with a poor prognosis. Despite extensive research, the underlying regulatory mechanisms of CRC remain unclear. Long noncoding RNAs (lncRNAs) are a major type of noncoding RNAs that have received increasing attention in the past few years, and studies have shown that they play a role in many biological processes in CRC. Here, we summarize recent studies on lncRNAs associated with CRC and the signaling pathways and mechanisms underlying this association. We show that dysregulated lncRNAs may be new prognostic and diagnostic biomarkers or therapeutic targets for clinical application. This review contributes not only to our understanding of CRC, but also suggests novel signaling pathways associated with lncRNAs that can be targeted to block or eradicate CRC.
