Disruption of the Gut Ecosystem by Antibiotics
- Author:
Mi Young YOON
1
;
Sang Sun YOON
Author Information
- Publication Type:Review
- Keywords: Microbiota; antibiotics; fecal microbiota transplantation (FMT); probiotics; enteric pathogen
- MeSH: Anti-Bacterial Agents/pharmacology; Bacteria/drug effects; Bacteria/growth & development; Dysbiosis/microbiology; Gastrointestinal Microbiome/drug effects; Humans; Intestines/drug effects; Intestines/microbiology; Symbiosis/drug effects
- From:Yonsei Medical Journal 2018;59(1):4-12
- CountryRepublic of Korea
- Language:English
- Abstract: The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression of each process leads to changes in the intestinal environment. Alterations in microbial communities lead to changes in functional structures based on the metabolites produced in the gut, and these environmental changes result in various bacterial infections and chronic enteric inflammatory diseases. Here, we illustrate how antibiotics are associated with an increased risk of antibiotic-associated diseases by driving intestinal environment changes that favor the proliferation and virulence of pathogens. Understanding the pathogenesis caused by antibiotics would be a crucial key to the treatment of antibiotic-associated diseases by mitigating changes in the intestinal environment and restoring it to its original state.
