Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox
- Author:
Soonchang HONG
1
;
Ji Hyun LEE
;
Kyung Min KIM
;
Jun Won LEE
;
Young Jin YOUN
;
Min Soo AHN
;
Sung Gyun AHN
;
Seung Hwan LEE
;
Junghan YOON
;
Kyung Hoon CHOE
;
Byung Su YOO
Author Information
- Publication Type:Original Article
- Keywords: Obesity; heart failure; systolic; sex difference
- MeSH: Aged; Body Mass Index; Demography; Endpoint Determination; Female; Heart Failure, Systolic/complications; Heart Failure, Systolic/epidemiology; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Obesity/complications; Obesity/epidemiology; Sex Characteristics; Treatment Outcome
- From:Yonsei Medical Journal 2018;59(1):57-62
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Obesity is often associated with better clinical outcomes in heart failure (HF). This so-called obesity paradox remains controversial. The aim of present study was to investigate the prognostic value of obesity in patients hospitalized for systolic HF. MATERIALS AND METHODS: We performed a pooled analysis of data from two multicenter, observational HF studies. Patients hospitalized for systolic HF were eligible for the present study. We divided the subjects into two groups, a normal body mass index (BMI) group and a high BMI group. Study endpoints included all-cause mortality and any re-hospitalization within 1 year. RESULTS: We enrolled 3145 patients (male, 1824; female, 1321). The high BMI group was significantly associated with lower 1-year mortality rate [odds ratio (OR), 0.543; 95% confidence interval (CI), 0.355−0.832] after adjusting for age, hypertension, diabetes, ischemic HF, previous myocardial infarction, serum creatinine level, anemia, and ejection fraction in men. After adjustment for clinical characteristics, high BMI was not significantly associated with 1-year mortality (OR, 0.739; 95% CI, 0.450−1.216) or 1-year re-hospitalization (OR, 0.958; 95% CI, 0.696−1.319) in women. CONCLUSION: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men.
