Pharmacodynamic principles and the time course of delayed and cumulative drug effects
10.12793/tcp.2018.26.2.56
- Author:
Nick HOLFORD
1
Author Information
1. Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand. n.holford@auckland.ac.nz
- Publication Type:Review
- Keywords:
Cumulative response;
Delayed of drug effect;
Receptor binding;
Turnover models
- MeSH:
Dose-Response Relationship, Drug;
Models, Biological
- From:Translational and Clinical Pharmacology
2018;26(2):56-59
- CountryRepublic of Korea
- Language:English
-
Abstract:
This tutorial reviews the principles of the concentration — effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining delay are distribution from the circulation to the receptor, binding to the receptor to produce a stimulus and translation of the receptor stimulus into an effect through turnover of physiological mediators. Some clinical outcomes are dependent on the accumulation of drug action which is predictable in terms of basic pharmacokinetic and pharmacodynamic concepts.
