A Case of Multiple Myeloma in a Patient with Systemic Lupus Erythematosus.
- Author:
Soo Jung LEE
1
;
Shin Seok LEE
;
Yun A KIM
;
Mi Jeong PARK
;
Je Jung LEE
;
Hyeoung Joon KIM
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. shinseok@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic lupus erythematosus;
Multiple myeloma
- MeSH:
Arthralgia;
Arthritis;
Bone Marrow;
Diagnosis;
Elbow Joint;
Electrophoresis;
Female;
Humans;
Hypergammaglobulinemia;
Immunoelectrophoresis;
Immunoglobulin G;
Immunoglobulins;
Korea;
Lupus Erythematosus, Systemic*;
Lupus Nephritis;
Middle Aged;
Models, Animal;
Multiple Myeloma*;
Neutropenia;
Plasma Cells;
Plasmacytoma
- From:The Journal of the Korean Rheumatism Association
2002;9(4):325-329
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It has been suggested that there is an increased risk of cancer in patients with systemic lupus erythematosus (SLE), even when cytotoxic drugs are not used. The coincidence of plasma cell tumor and lupus nephritis has been documented in animal models, but multiple myeloma is rarely associated with SLE in humans. No case of multiple myeloma in SLE has been reported in Korea. We report a case of multiple myeloma in a patient with SLE. The patient was a 49-year-old woman, who had polyarthralgia for 2 years. Progressive, painful swelling in both elbow joints developed 3 months before admission. The diagnosis of SLE was based on the findings of nondeforming arthritis, neutropenia, and positive ANA and anti-Sm antibody. Laboratory studies showed hypergammaglobulinemia and an elevated serum immunoglobulin (Ig) G level. Serum protein electrophoresis disclosed an M spike and serum immunoelectrophoresis showed a monoclonal IgG lambda type. Bone marrow aspiration revealed 15% plasma cells. Therefore, we diagnosed this patient as having multiple myeloma and SLE simultaneously.
