Extracorporeal Life Support in Adult Patients with Hematologic Malignancies and Acute Circulatory and/or Respiratory Failure
10.5090/kjtcs.2019.52.1.25
- Author:
Sungbin CHO
1
;
Won Chul CHO
;
Ju Yong LIM
;
Pil Je KANG
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine. kfeelj78@gmail.com
- Publication Type:Original Article
- Keywords:
Extracorporeal membrane oxygenation;
Hematologic neoplasms;
Adult;
Mortality
- MeSH:
Adult;
Chungcheongnam-do;
Extracorporeal Membrane Oxygenation;
Extremities;
Female;
Hematologic Neoplasms;
Hemorrhage;
Hospital Mortality;
Humans;
Intensive Care Units;
Ischemia;
Mortality;
Observational Study;
Respiratory Insufficiency;
Retrospective Studies
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2019;52(1):25-31
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The primary goal of this study was to characterize the clinical outcomes of adult patients with hematologic malignancies (HM) who were treated with extracorporeal membrane oxygenation (ECMO) support when conventional treatments failed. METHODS: In this retrospective, observational study at a tertiary medical center, we reviewed the clinical course of 23 consecutive patients with HM requiring ECMO who were admitted to the intensive care unit at Asan Medical Center from March 2010 to April 2015. RESULTS: A total of 23 patients (8 female; median age, 44 years; range, 29–51 years) with HM and severe acute circulatory and/or respiratory failure received ECMO therapy during the study period. Fourteen patients received veno-arterial ECMO, while 9 patients received veno-venous ECMO. The median ECMO duration was 104.7 hours (range, 37.1–221 hours). Nine patients were successfully weaned from ECMO. The in-hospital mortality rate was 91.1% (21 of 23). There were complications in 3 patients (cannulation site bleeding, limb ischemia, and gastrointestinal bleeding). CONCLUSION: ECMO is a useful treatment for patients with circulatory and/or pulmonary failure. However, in patients with HM, the outcomes of ECMO treatment results were very poor, so it is advisable to carefully decide whether to apply ECMO to these patients.
