Outcomes of Pulmonary Resection and Mediastinal Node Dissection by Video-Assisted Thoracoscopic Surgery Following Neoadjuvant Chemoradiation Therapy for Stage IIIA N2 Non-Small Cell Lung Cancer
10.5090/kjtcs.2018.51.1.29
- Author:
Yeong Jeong JEON
1
;
Yong Soo CHOI
;
Kyung Jong LEE
;
Se Hoon LEE
;
Hongryull PYO
;
Joon Young CHOI
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. ysooyah.choi@samsung.com
- Publication Type:Original Article
- Keywords:
Non-small-cell lung carcinoma;
Neoadjuvant therapy;
Video-assisted thoracoscopic surgery;
Lobectomy
- MeSH:
Carbon Monoxide;
Carcinoma, Non-Small-Cell Lung;
Chest Tubes;
Disease-Free Survival;
Drainage;
Follow-Up Studies;
Humans;
Lung Neoplasms;
Methods;
Mortality;
Neoadjuvant Therapy;
Postoperative Complications;
Retrospective Studies;
Survival Rate;
Thoracic Surgery, Video-Assisted;
Thoracotomy
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2018;51(1):29-34
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We evaluated the feasibility and outcomes of pulmonary resection and mediastinal node dissection (MND) by video-assisted thoracoscopic surgery (VATS) following neoadjuvant therapy for stage IIIA N2 non-small cell lung cancer (NSCLC). METHODS: From November 2009 to December 2013, a total of 35 consecutive patients with pathologically or radiologically confirmed stage IIIA N2 lung cancer underwent pulmonary resection and MND, performed by a single surgeon, following neoadjuvant chemoradiation. Preoperative patient characteristics, surgical outcomes, postoperative drainage, postoperative complications, and mortality were retrospectively analyzed. RESULTS: VATS was completed in 17 patients. Thoracotomy was performed in 18 patients, with 13 planned thoracotomies and 5 conversions from the VATS approach. The median age was 62.7±7.9 years in the VATS group and 60±8.7 years in the thoracotomy group. The patients in the VATS group tended to have a lower diffusing capacity for carbon monoxide (p=0.077). There were no differences between the 2 groups in the method of diagnosing the N stage, tumor response and size after induction, tumor location, or histologic type. Complete resection was achieved in all patients. More total and mediastinal nodes were dissected in the VATS group than in the thoracotomy group (p < 0.05). The median chest tube duration was 5.3 days (range, 1 to 33 days) for the VATS group and 7.2 days (range, 2 to 28 days) for the thoracotomy group. The median follow-up duration was 36.3 months. The 5-year survival rates were 76% in the VATS group and 57.8% in the thoracotomy group (p=0.39). The 5-year disease-free survival rates were 40.3% and 38.9% in the VATS and thoracotomy groups, respectively (p=0.8). CONCLUSION: The VATS approach following neoadjuvant treatment was safe and feasible in selected patients for the treatment of stage IIIA N2 NSCLC, with no compromise of oncologic efficacy.
